Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ

Nilotinib and imatinib are tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). In vitro, imatinib and nilotinib inhibit osteoclastogenesis, and in patients they reduce levels of bone resorption. One of the mechanisms t...

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Foilsithe in:PLoS One
Main Authors: O’Sullivan, Susannah, Tay, Mei Lin, Lin, Jian-Ming, Bava, Usha, Callon, Karen, Cornish, Jillian, Naot, Dorit, Grey, Andrew
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063333/
https://ncbi.nlm.nih.gov/pubmed/27737004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164727
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