Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ

Nilotinib and imatinib are tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). In vitro, imatinib and nilotinib inhibit osteoclastogenesis, and in patients they reduce levels of bone resorption. One of the mechanisms t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: O’Sullivan, Susannah, Tay, Mei Lin, Lin, Jian-Ming, Bava, Usha, Callon, Karen, Cornish, Jillian, Naot, Dorit, Grey, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063333/
https://ncbi.nlm.nih.gov/pubmed/27737004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164727
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