Intracranial and whole-body response of ceritinib in ALK inhibitor-naïve and previously ALK inhibitor-treated patients with ALK-rearranged non-small-cell lung cancer (NSCLC): updated results from the phase 1, multicentre, open-label ASCEND-1 trial

BACKGROUND: ALK-rearranged non-small-cell lung cancer (NSCLC) is sensitive to ALK tyrosine kinase inhibitors (ALKi) such as crizotinib, but resistance invariably develops, often with progression in the brain. Ceritinib is a more potent ALKi than crizotinib in vitro, crosses the blood-brain barrier i...

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Udgivet i:Lancet Oncol
Main Authors: Kim, Dong-Wan, Mehra, Ranee, Tan, Daniel S W, Felip, Enriqueta, Chow, Laura Q M, Camidge, D Ross, Vansteenkiste, Johan, Sharma, Sunil, De Pas, Tommaso, Riely, Gregory J, Solomon, Benjamin J, Wolf, Jürgen, Thomas, Michael, Schuler, Martin, Liu, Geoffrey, Santoro, Armando, Sutradhar, Santosh, Li, Siyu, Szczudlo, Tomasz, Yovine, Alejandro, Shaw, Alice T
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063047/
https://ncbi.nlm.nih.gov/pubmed/26973324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(15)00614-2
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