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ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling and oxidative stress have been implicated in the pathogenesis of the ALS-FTLD spectrum of neurodegenerative disorders. The Keap1-binding partn...
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| Publicado no: | Mol Cell Neurosci |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Academic Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5062946/ https://ncbi.nlm.nih.gov/pubmed/27554286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2016.08.004 |
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