Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD

Growing evidence implicates impairment of autophagy as a candidate pathogenic mechanism in the spectrum of neurodegenerative disorders which includes amyotrophic lateral sclerosis and frontotemporal lobar degeneration (ALS-FTLD). SQSTM1, which encodes the autophagy receptor SQSTM1/p62, is geneticall...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Goode, Alice, Butler, Kevin, Long, Jed, Cavey, James, Scott, Daniel, Shaw, Barry, Sollenberger, Jill, Gell, Christopher, Johansen, Terje, Oldham, Neil J., Searle, Mark S., Layfield, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990988/
https://ncbi.nlm.nih.gov/pubmed/27158844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1170257
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