Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family G protein, Rac1, regulate interleukin (IL)17A transcription and autoimmunit...

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發表在:Nat Commun
Main Authors: Kurdi, Ahmed T., Bassil, Ribal, Olah, Marta, Wu, Chuan, Xiao, Sheng, Taga, Mariko, Frangieh, Michael, Buttrick, Thomas, Orent, William, Bradshaw, Elizabeth M., Khoury, Samia J., Elyaman, Wassim
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062600/
https://ncbi.nlm.nih.gov/pubmed/27725632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13048
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