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Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
Circadian rhythms controlled by clock genes affect plasma lipids. Here we show that global ablation of Bmal1 in Apoe(−/−) and Ldlr(−/−) mice and its liver-specific ablation in Apoe(−/−) (L-Bmal1(−/−)Apoe(−/−)) mice increases, whereas overexpression of BMAL1 in L-Bmal1(−/−)Apoe(−/−) and Apoe(−/−)mice...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5062545/ https://ncbi.nlm.nih.gov/pubmed/27721414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13011 |
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