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First‐in‐human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males

AIMS: The aim of the present study was to investigate the safety, tolerability, dose proportionality and relative bioavailability of tablet and oral solution formulations of BI 409306 in healthy male subjects, and to compare the safety and pharmacokinetics in subjects who were extensive metabolizers...

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書目詳細資料
發表在:Br J Clin Pharmacol
Main Authors: Moschetti, Viktoria, Boland, Katja, Feifel, Ulrich, Hoch, Anja, Zimdahl‐Gelling, Heike, Sand, Michael
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061793/
https://ncbi.nlm.nih.gov/pubmed/27378314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13060
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