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First‐in‐human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males

AIMS: The aim of the present study was to investigate the safety, tolerability, dose proportionality and relative bioavailability of tablet and oral solution formulations of BI 409306 in healthy male subjects, and to compare the safety and pharmacokinetics in subjects who were extensive metabolizers...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Moschetti, Viktoria, Boland, Katja, Feifel, Ulrich, Hoch, Anja, Zimdahl‐Gelling, Heike, Sand, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061793/
https://ncbi.nlm.nih.gov/pubmed/27378314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13060
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