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Quantification of Cellular and Nuclear Uptake Rates of Polymeric Gene Delivery Nanoparticles and DNA Plasmids via Flow Cytometry

Non-viral, biomaterial-mediated gene delivery has the potential to treat many diseases, but is limited by low efficacy. Elucidating the bottlenecks of plasmid mass transfer can enable an improved understanding of biomaterial structure-function relationships, leading to next-generation rationally des...

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Detalhes bibliográficos
Publicado no:Acta Biomater
Main Authors: Bishop, Corey J., Majewski, Rebecca L., Guiriba, Toni-Rose M., Wilson, David R., Bhise, Nupura S., Quiñones-Hinojosa, Alfredo, Green, Jordan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061650/
https://ncbi.nlm.nih.gov/pubmed/27019146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2016.03.036
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