TLR2-expressing macrophages are required and sufficient for rhinovirus-induced airway inflammation

BACKGROUND: We have shown that rhinovirus (RV), a cause of asthma exacerbations, colocalizes with CD68- and CD11b-positive airway macrophages following experimental infection in humans. We have also shown that RV-induced cytokine expression is abolished in TLR2−/− bone marrow-derived macrophages. OB...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Han, Mingyuan, Chung, Yutein, Hong, Jun Young, Rajput, Charu, Lei, Jing, Hinde, Joanna L., Chen, Qiang, Weng, Steven T., Bentley, J. Kelley, Hershenson, Marc B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061583/
https://ncbi.nlm.nih.gov/pubmed/27084403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.01.037
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