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Repurposing the Clinically Efficacious Anti-Fungal Agent Itraconazole as an Anti-Cancer Chemotherapeutic

Itraconazole (ITZ) is an FDA-approved member of the triazole class of anti-fungal agents. Two recent drug repurposing screens identified ITZ as a promising anti-cancer chemotherapeutic that inhibits both angiogenesis and the hedgehog (Hh) signaling pathway. We have synthesized and evaluated first an...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Pace, Jennifer R., DeBerardinis, Albert M., Sail, Vibhavari, Tacheva-Grigorova, Silvia K., Chan, Kelly A., Tran, Raymond, Raccuia, Daniel S., Wechsler-Reya, Robert J., Hadden, M. Kyle
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061146/
https://ncbi.nlm.nih.gov/pubmed/27014922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01718
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