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Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model

BACKGROUND: Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultane...

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Dettagli Bibliografici
Pubblicato in:BMC Cancer
Autori principali: Ding, Chenbo, Li, Longmei, Yang, Taoyu, Fan, Xiaobo, Wu, Guoqiu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059930/
https://ncbi.nlm.nih.gov/pubmed/27729020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2834-8
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