Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

Macrophages express TNFR1 as well as TNFR2 and are also major producers of tumor necrosis factor (TNF), especially upon contact with pathogen-associated molecular patterns. Consequently, TNF not only acts as a macrophage-derived effector molecule but also regulates the activity and viability of macr...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Siegmund, Daniela, Kums, Juliane, Ehrenschwender, Martin, Wajant, Harald
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059883/
https://ncbi.nlm.nih.gov/pubmed/27899821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.285
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