Aberrant Splicing Promotes Proteasomal Degradation of L-type Ca(V)1.2 Calcium Channels by Competitive Binding for Ca(V)β Subunits in Cardiac Hypertrophy

Decreased expression and activity of Ca(V)1.2 calcium channels has been reported in pressure overload-induced cardiac hypertrophy and heart failure. However, the underlying mechanisms remain unknown. Here we identified in rodents a splice variant of Ca(V)1.2 channel, named Ca(V)1.2(e21+22), that con...

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Pubblicato in:Sci Rep
Autori principali: Hu, Zhenyu, Wang, Jiong-Wei, Yu, Dejie, Soon, Jia Lin, de Kleijn, Dominique P. V., Foo, Roger, Liao, Ping, Colecraft, Henry M., Soong, Tuck Wah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059693/
https://ncbi.nlm.nih.gov/pubmed/27731386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35247
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