ロード中...
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3
Spinocerebellar ataxia type-3 (SCA3) is a neurodegenerative disorder caused by a polyglutamine repeat expansion in the ataxin-3 protein. Cleavage of mutant ataxin-3 by proteolytic enzymes yields ataxin-3 fragments containing the polyglutamine stretch. These shorter ataxin-3 fragments are thought to...
保存先:
| 出版年: | Sci Rep |
|---|---|
| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
|
| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5059676/ https://ncbi.nlm.nih.gov/pubmed/27731380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35200 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|