Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform that is overexpressed in several cancers and has been implicated in drug resistance. Currently, no small-molecule drug targeting GSTO1 is under clinical development. Here we show that silencing of GSTO1 with siRNA significantly imp...

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Pubblicato in:Nat Commun
Autori principali: Ramkumar, Kavya, Samanta, Soma, Kyani, Anahita, Yang, Suhui, Tamura, Shuzo, Ziemke, Elizabeth, Stuckey, Jeanne A., Li, Si, Chinnaswamy, Krishnapriya, Otake, Hiroyuki, Debnath, Bikash, Yarovenko, Vladimir, Sebolt-Leopold, Judith S., Ljungman, Mats, Neamati, Nouri
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059489/
https://ncbi.nlm.nih.gov/pubmed/27703239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13084
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