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Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
Elimination of misfolded proteins is crucial for proteostasis and to prevent proteinopathies. Nedd4/Rsp5 emerged as a major E3-ligase involved in multiple quality control pathways that target misfolded plasma membrane proteins, aggregated polypeptides and cytosolic heat-induced misfolded proteins fo...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5059457/ https://ncbi.nlm.nih.gov/pubmed/27698423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12907 |
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