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Comparative survey of the relative impact of mRNA features on local ribosome profiling read density

Ribosome profiling (Ribo-seq), a promising technology for exploring ribosome decoding rates, is characterized by the presence of infrequent high peaks in ribosome footprint density and by long alignment gaps. Here, to reduce the impact of data heterogeneity we introduce a simple normalization method...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: O'Connor, Patrick B. F., Andreev, Dmitry E., Baranov, Pavel V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059445/
https://ncbi.nlm.nih.gov/pubmed/27698342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12915
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