CUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis

It has been shown that HPV16 E7, but not other genotypes, can bind to scaffold protein CUL2 during inducing cervical carcinogenesis, but the expression level, associated regulating mechanism, and potential carcinogenicity of CUL2 itself is still unknown as yet. Here, we demonstrated that CUL2 was sp...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Xu, Junfen, Fang, Yifeng, Wang, Xinyu, Wang, Fenfen, Tian, Qifang, Li, Ying, Xie, Xing, Cheng, Xiaodong, Lu, Weiguo
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058775/
https://ncbi.nlm.nih.gov/pubmed/27153550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9127
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