CUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis

It has been shown that HPV16 E7, but not other genotypes, can bind to scaffold protein CUL2 during inducing cervical carcinogenesis, but the expression level, associated regulating mechanism, and potential carcinogenicity of CUL2 itself is still unknown as yet. Here, we demonstrated that CUL2 was sp...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xu, Junfen, Fang, Yifeng, Wang, Xinyu, Wang, Fenfen, Tian, Qifang, Li, Ying, Xie, Xing, Cheng, Xiaodong, Lu, Weiguo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058775/
https://ncbi.nlm.nih.gov/pubmed/27153550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9127
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