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Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability

INTRODUCTION: Loss of synapses best correlates to cognitive deficits in Alzheimer's disease (AD) in which oligomeric neurotoxic species of amyloid β appears to contribute synaptic pathology. While a number of clinical pathological studies have been performed with limited sample size, there are...

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Bibliographic Details
Published in:Alzheimers Dement
Main Authors: de Wilde, Martijn C, Overk, Cassia R, Sijben, John W, Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058345/
https://ncbi.nlm.nih.gov/pubmed/26776762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.12.005
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