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Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine.

Tacrine has been studied in two clinical trials of identical design in patients with probable Alzheimer disease. One trial enrolled patients in the United States, while the other enrolled patients in France. A population pharmacodynamic model has been used to describe the cognitive component of the...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Holford, N H, Peace, K E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 1992
Aiheet:
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50573/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1454836/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.23.11471
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