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Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in Hereditary Multiple Exostoses

Hereditary multiple exostoses (HME) is a rare childhood-onset skeletal disease linked to mutations in exostosin glycosyltransferase 1 (EXT1) or 2 (EXT2). Patients are heterozygous for either an EXT1 or EXT2 mutation, and it is widely assumed that exostosis formation and associated defects, such as g...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bone
Prif Awduron: Cousminer, Diana L., Arkader, Alexandre, Voight, Benjamin F., Pacifici, Maurizio, Grant, Struan F. A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056851/
https://ncbi.nlm.nih.gov/pubmed/27616605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2016.09.005
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