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Paternal Age Explains a Major Portion of De Novo Germline Mutation Rate Variability in Healthy Individuals

De novo mutations (DNM) are an important source of rare variants and are increasingly being linked to the development of many diseases. Recently, the paternal age effect has been the focus of a number of studies that attempt to explain the observation that increasing paternal age increases the risk...

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הוצא לאור ב:	PLoS One
Main Authors:	Girard, Simon L., Bourassa, Cynthia V., Lemieux Perreault, Louis-Philippe, Legault, Marc-André, Barhdadi, Amina, Ambalavanan, Amirthagowri, Brendgen, Mara, Vitaro, Frank, Noreau, Anne, Dionne, Ginette, Tremblay, Richard E., Dion, Patrick A., Boivin, Michel, Dubé, Marie-Pierre, Rouleau, Guy A.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science 2016
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5056704/ https://ncbi.nlm.nih.gov/pubmed/27723766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164212
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Paternal Age Explains a Major Portion of De Novo Germline Mutation Rate Variability in Healthy Individuals

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