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Paternal Age Explains a Major Portion of De Novo Germline Mutation Rate Variability in Healthy Individuals

De novo mutations (DNM) are an important source of rare variants and are increasingly being linked to the development of many diseases. Recently, the paternal age effect has been the focus of a number of studies that attempt to explain the observation that increasing paternal age increases the risk...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Girard, Simon L., Bourassa, Cynthia V., Lemieux Perreault, Louis-Philippe, Legault, Marc-André, Barhdadi, Amina, Ambalavanan, Amirthagowri, Brendgen, Mara, Vitaro, Frank, Noreau, Anne, Dionne, Ginette, Tremblay, Richard E., Dion, Patrick A., Boivin, Michel, Dubé, Marie-Pierre, Rouleau, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056704/
https://ncbi.nlm.nih.gov/pubmed/27723766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164212
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