Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen.

Oxidative damage to DNA induced by singlet molecular oxygen (1O2*) includes single-strand breaks, which the biologically occurring 1O2* quenchers spermine and spermidine are shown to prevent. These polyamines at a physiological concentration (10 mM) reduce the percentage of the open circular form of...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Khan, A U, Di Mascio, P, Medeiros, M H, Wilson, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50564/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1454831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.23.11428
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