Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices

BACKGROUND AND PURPOSE: Asthma presents as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyper‐reactivity (AHR). Spleen tyrosine kinase (Syk) mediates allergen‐induced mast cell degranulation, a central component of allergen‐induced inflammation and AHR. However, the...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Koziol‐White, Cynthia J, Jia, Yanlin, Baltus, Gretchen A, Cooper, Philip R, Zaller, Dennis M, Crackower, Michael A, Sirkowski, Erich E, Smock, Steven, Northrup, Alan B, Himes, Blanca E, Alves, Stephen E, Panettieri, Reynold A
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056227/
https://ncbi.nlm.nih.gov/pubmed/27417329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13550
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi