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C-027 Inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways

Atopic asthma is poorly controlled by current therapies. Newer therapies and novel antihistamines are, therefore, required to treat patients whose atopic asthma is not controlled. For the first time, C-027 is shown to antagonize histamine, IgE-mediated and serotonin-induced contraction in human airw...

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Detalhes bibliográficos
Main Authors: Cooper, Philip R., Zhang, Jie, Damera, Gautam, Hoshi, Toshinori, Zopf, David A., Panettieri, Reynold A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968313/
https://ncbi.nlm.nih.gov/pubmed/22195688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2500/aap.2011.32.3460
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