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Trichostatin A Abrogates Airway Constriction, but Not Inflammation, in Murine and Human Asthma Models
Histone deacetylase (HDAC) inhibitors may offer novel approaches in the treatment of asthma. We postulate that trichostatin A (TSA), a Class 1 and 2 inhibitor of HDAC, inhibits airway hyperresponsiveness in antigen-challenged mice. Mice were sensitized and challenged with Aspergillus fumigatus antig...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Thoracic Society
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3297166/ https://ncbi.nlm.nih.gov/pubmed/22298527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2010-0276OC |
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