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Trichostatin A Abrogates Airway Constriction, but Not Inflammation, in Murine and Human Asthma Models

Histone deacetylase (HDAC) inhibitors may offer novel approaches in the treatment of asthma. We postulate that trichostatin A (TSA), a Class 1 and 2 inhibitor of HDAC, inhibits airway hyperresponsiveness in antigen-challenged mice. Mice were sensitized and challenged with Aspergillus fumigatus antig...

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Detalhes bibliográficos
Main Authors: Banerjee, Audreesh, Trivedi, Chinmay M., Damera, Gautam, Jiang, Meiqi, Jester, William, Hoshi, Toshinori, Epstein, Jonathan A., Panettieri, Reynold A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297166/
https://ncbi.nlm.nih.gov/pubmed/22298527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2010-0276OC
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