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SPECT Imaging of Inflammatory Response in Ischemic–Reperfused Rat Hearts Using a (99m)Tc-Labeled Dual-Domain Cytokine Ligand
Soluble tumor necrosis factor (TNF) receptor-2 (TNFR2) and interleukin-1 receptor antagonist (IL-1ra) were fused to the Fc portion of IgG1 using recombinant DNA technology. The resulting dual-domain cytokine ligand, TNFR2-Fc-IL-1ra, specifically binds to TNF and to the type I IL-1 receptor (IL-1RI)....
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| Veröffentlicht in: | J Nucl Med |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055402/ https://ncbi.nlm.nih.gov/pubmed/24179185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.113.123497 |
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