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Characterization of (99m)Tc-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways

INTRODUCTION: TNFR2-Fc and IL-1ra-Fc are recombinant cytokine ligands that target TNF and IL-1. TNFR2-Fc-IL-1ra, a dual-domain agent that incorporates both ligands, allows bifunctional binding of IL-1 receptors and TNF. This study was designed to characterize (99m)Tc-labeled forms of these ligands,...

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Bibliografiske detaljer
Main Authors: Liu, Zhonglin, wyffels, Leonie, Barber, Christy, Wan, Li, Xu, Hua, Hui, Mizhou M., Furenlid, Lars R., Woolfenden, James M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443298/
https://ncbi.nlm.nih.gov/pubmed/22749187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2012.05.003
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