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Gdown1 Associates Efficiently with RNA Polymerase II after Promoter Clearance and Displaces TFIIF during Transcript Elongation

Pausing during the earliest stage of transcript elongation by RNA polymerase II (Pol II) is a nearly universal control point in metazoan gene expression. The substoichiometric Pol II subunit Gdown1 facilitates promoter proximal pausing in vitro in extract-based transcription reactions, out-competes...

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Veröffentlicht in:PLoS One
Hauptverfasser: DeLaney, Elizabeth, Luse, Donal S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055313/
https://ncbi.nlm.nih.gov/pubmed/27716820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163649
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