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Activation of transmembrane cell‐surface receptors via a common mechanism? The “rotation model”
It has long been thought that transmembrane cell‐surface receptors, such as receptor tyrosine kinases and cytokine receptors, among others, are activated by ligand binding through ligand‐induced dimerization of the receptors. However, there is growing evidence that prior to ligand binding, various t...
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| Publicado en: | Bioessays |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5054922/ https://ncbi.nlm.nih.gov/pubmed/26241732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201500041 |
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