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Bcl11a-deficiency leads to hematopoietic stem cell defects with an aging-like phenotype
B cell CLL/lymphoma 11A (BCL11A) is a transcription factor and regulator of hemoglobin switching that has emerged as a promising therapeutic target for sickle cell disease and thalassemia. In the hematopoietic system, BCL11A is required for B lymphopoiesis, yet its role in other hematopoietic cells,...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5054719/ https://ncbi.nlm.nih.gov/pubmed/27653684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.064 |
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