Species Comparison of Pre-systemic Bioactivation of Vicagrel, a New Acetate Derivative of Clopidogrel

Previously we have found vicagrel, a new acetate derivative of clopidogrel, underwent hydrolysis to 2-oxo-clopidogrel and subsequent conversions to its pharmacological active metabolite (AM) and inactive carboxylic acid metabolite (CAM). This study demonstrated the interspecies differences of the vi...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Qiu, Zhi-xia, Gao, Wen-chao, Dai, Yu, Zhou, Su-feng, Zhao, Jie, Lu, Yang, Chen, Xi-jing, Li, Ning
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054534/
https://ncbi.nlm.nih.gov/pubmed/27774067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00366
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