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Transcriptome–metabolome wide association study (TMWAS) of maneb and paraquat neurotoxicity reveals network level interactions in toxicologic mechanism

A combination of the herbicide paraquat (PQ) and fungicide maneb (MB) has been linked to Parkinson's disease. Previous studies show that this involves an additive toxicity with at least two different mechanisms. However, detailed understanding of mixtures is often difficult to elucidate because...

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Dettagli Bibliografici
Pubblicato in:Toxicol Rep
Autori principali: Roede, James R., Uppal, Karan, Park, Youngja, Tran, ViLinh, Jones, Dean P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053767/
https://ncbi.nlm.nih.gov/pubmed/27722094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2014.07.006
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