Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier

Central nervous system (CNS) infection continues to be an important cause of mortality and morbidity, necessitating new approaches for investigating its pathogenesis, prevention and therapy. Escherichia coli is the most common Gram-negative bacillary organism causing meningitis, which develops follo...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Wang, Xiangru, Maruvada, Ravi, Morris, Andrew J., Liu, Jun O., Wolfgang, Michael J., Baek, Dong Jae, Bittman, Robert, Kim, Kwang Sik
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053521/
https://ncbi.nlm.nih.gov/pubmed/27711202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005926
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