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Filaggrin failure – from ichthyosis vulgaris to atopic eczema and beyond

The main proteinaceous component of the keratohyalin granules within the granular layer keratinocytes of the epidermis is the giant, repetitive polyprotein profilaggrin. When granular layer cells commit to terminal differentiation to form the flattened squames of the stratum corneum, profilaggrin is...

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Detalles Bibliográficos
Publicado en:Br J Dermatol
Autor Principal: McLean, W.H.I.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053269/
https://ncbi.nlm.nih.gov/pubmed/27667308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjd.14997
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