Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity

Huntington’s disease is one of nine neurodegenerative diseases caused by a polyglutamine (polyQ)-repeat expansion. An anti-polyQ antigen-binding fragment, MW1 Fab, was crystallized both on Earth and on the International Space Station, a microgravity environment where convection is limited. Once the...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Owens, Gwen E., New, Danielle M., Olvera, Alejandra I., Manzella, Julia Ashlyn, Macon, Brittney L., Dunn, Joshua C., Cooper, David A., Rouleau, Robyn L., Connor, Daniel S., Bjorkman, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2016
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053161/
https://ncbi.nlm.nih.gov/pubmed/27710941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16014011
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