Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin

Aberrant wnt/β-catenin signaling and amplification/overexpression of Myc are associated with hepatoblastoma (HB), the most prevalent type of childhood liver cancer. To address their roles in the pathogenesis of HB, we generated mice in which Myc and mutant β-catenin were targeted to immature cells o...

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Publicado en:JCI Insight
Autores principales: Comerford, Sarah A., Hinnant, Elizabeth A., Chen, Yidong, Bansal, Hima, Klapproth, Shawn, Rakheja, Dinesh, Finegold, Milton J., Lopez-Terrada, Dolores, O’Donnell, Kathryn A., Tomlinson, Gail E., Hammer, Robert E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053152/
https://ncbi.nlm.nih.gov/pubmed/27734029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88549
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