Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin

Aberrant wnt/β-catenin signaling and amplification/overexpression of Myc are associated with hepatoblastoma (HB), the most prevalent type of childhood liver cancer. To address their roles in the pathogenesis of HB, we generated mice in which Myc and mutant β-catenin were targeted to immature cells o...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Comerford, Sarah A., Hinnant, Elizabeth A., Chen, Yidong, Bansal, Hima, Klapproth, Shawn, Rakheja, Dinesh, Finegold, Milton J., Lopez-Terrada, Dolores, O’Donnell, Kathryn A., Tomlinson, Gail E., Hammer, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053152/
https://ncbi.nlm.nih.gov/pubmed/27734029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88549
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