Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin

Aberrant wnt/β-catenin signaling and amplification/overexpression of Myc are associated with hepatoblastoma (HB), the most prevalent type of childhood liver cancer. To address their roles in the pathogenesis of HB, we generated mice in which Myc and mutant β-catenin were targeted to immature cells o...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Comerford, Sarah A., Hinnant, Elizabeth A., Chen, Yidong, Bansal, Hima, Klapproth, Shawn, Rakheja, Dinesh, Finegold, Milton J., Lopez-Terrada, Dolores, O’Donnell, Kathryn A., Tomlinson, Gail E., Hammer, Robert E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053152/
https://ncbi.nlm.nih.gov/pubmed/27734029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88549
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