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Composite sequential Monte Carlo test for post-market vaccine safety surveillance

Group sequential hypothesis testing is now widely used to analyze prospective data. If Monte Carlo simulation is used to construct the signaling threshold, the challenge is how to manage the type I error probability for each one of the multiple tests without losing control on the overall significanc...

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Bibliographic Details
Published in:Stat Med
Main Author: Silva, Ivair R.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052811/
https://ncbi.nlm.nih.gov/pubmed/26561330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6805
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