Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA,...

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Publié dans:Nat Commun
Auteurs principaux: Smid, Marcel, Rodríguez-González, F. Germán, Sieuwerts, Anieta M., Salgado, Roberto, Prager-Van der Smissen, Wendy J. C., Vlugt-Daane, Michelle van der, van Galen, Anne, Nik-Zainal, Serena, Staaf, Johan, Brinkman, Arie B., van de Vijver, Marc J., Richardson, Andrea L., Fatima, Aquila, Berentsen, Kim, Butler, Adam, Martin, Sancha, Davies, Helen R., Debets, Reno, Gelder, Marion E. Meijer-Van, van Deurzen, Carolien H. M., MacGrogan, Gaëtan, Van den Eynden, Gert G. G. M., Purdie, Colin, Thompson, Alastair M., Caldas, Carlos, Span, Paul N., Simpson, Peter T., Lakhani, Sunil R., Van Laere, Steven, Desmedt, Christine, Ringnér, Markus, Tommasi, Stefania, Eyford, Jorunn, Broeks, Annegien, Vincent-Salomon, Anne, Futreal, P. Andrew, Knappskog, Stian, King, Tari, Thomas, Gilles, Viari, Alain, Langerød, Anita, Børresen-Dale, Anne-Lise, Birney, Ewan, Stunnenberg, Hendrik G., Stratton, Mike, Foekens, John A., Martens, John W. M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052682/
https://ncbi.nlm.nih.gov/pubmed/27666519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12910
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