Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells

Cr(VI) compounds are known to cause serious toxic and carcinogenic effects. Cr(VI) exposure can lead to a severe damage to the skin, but the mechanisms involved in the Cr(VI)-mediated toxicity in the skin are unclear. The present study examined whether Cr(VI) induces cell death by apoptosis or necro...

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Vydáno v:Toxicol Appl Pharmacol
Hlavní autoři: Son, Young-Ok, Hitron, J. Andrew, Wang, Xin, Chang, Qingshan, Pan, Jingju, Zhang, Zhuo, Liu, Jiankang, Wang, Shuxia, Lee, Jeong-Chae, Shi, Xianglin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5051966/
https://ncbi.nlm.nih.gov/pubmed/20298709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.03.004
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