Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

Rotaviruses (RVs) are the leading cause of severe gastroenteritis in young children, accounting for half a million deaths annually worldwide. RV encodes non-structural protein 1 (NSP1), a well-characterized interferon (IFN) antagonist, which facilitates virus replication by mediating the degradation...

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Publicado en:PLoS Pathog
Main Authors: Ding, Siyuan, Mooney, Nancie, Li, Bin, Kelly, Marcus R., Feng, Ningguo, Loktev, Alexander V., Sen, Adrish, Patton, John T., Jackson, Peter K., Greenberg, Harry B.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5051689/
https://ncbi.nlm.nih.gov/pubmed/27706223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005929
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