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Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration
According to the amyloid hypothesis, the accumulation of oligomerized Aβ is a primary event in the pathogenesis of Alzheimer’s disease (AD). The trigger of the amyloid cascade and of Aβ oligomerization in sporadic AD, the most prevalent form of the disease, remains elusive. Here we examined the hypo...
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| Veröffentlicht in: | J Alzheimers Dis |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5051636/ https://ncbi.nlm.nih.gov/pubmed/20858958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-101008 |
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