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Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing

Aconitines, including bulleyaconitine A, probably the most bioactive and abundant alkaloids in Aconitum plant, are a group of diester C19-diterpenoid alkaloids with one acetylester group attached to C8 of the diterpenoid skeleton and one benzoylester group to C14. Hydrolysis of both groups is involv...

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Vydáno v:Front Pharmacol
Hlavní autoři: Li, Teng-Fei, Gong, Nian, Wang, Yong-Xiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5051147/
https://ncbi.nlm.nih.gov/pubmed/27761113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00367
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