VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions

BACKGROUND: Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to age- and disease-related degeneration of the motor system. Here we investigated...

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Dettagli Bibliografici
Pubblicato in:Skelet Muscle
Autori principali: Sugita, Satoshi, Fleming, Leland L., Wood, Caleb, Vaughan, Sydney K., Gomes, Matheus P. S. M., Camargo, Wallace, Naves, Ligia A., Prado, Vania F., Prado, Marco A. M., Guatimosim, Cristina, Valdez, Gregorio
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050580/
https://ncbi.nlm.nih.gov/pubmed/27713817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-016-0105-7
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