Pulmonary Hypertension in the Newborn GTP-Cyclohydrolase 1-Deficient Mouse

Tetrahydrobiopterin (BH4) is a regulator of endothelial nitric oxide synthase (eNOS) activity. Deficient levels result in eNOS uncoupling with a shift from nitric oxide (NO) to superoxide generation. The hph-1 mutant mouse has deficient GTP-cyclohydrolase 1 (GTPCH1) activity resulting in low BH4 tis...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Free Radic Biol Med
Huvudupphovsmän: Belik, Jaques, McIntyre, Brendan A.S., Enomoto, Masahiro, Pan, Jingyi, Grasemann, Hartmut, Vasquez-Vivar, Jeannette
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050525/
https://ncbi.nlm.nih.gov/pubmed/21982896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.09.012
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk